Joint Group G leaders Spain and Italy are locked together on 16 points, but with only top spot guaranteeing a place at the World Cup the nation that finishes second faces a play-off to qualify.
And Ramos called for Spain supporters to get behind his side and avoid whistling Pique, who has been targeted by fans in the past.
What we re concerned about is that there s a place at the World Cup at stake and, above all, it s at a grand stadium like the Santiago Bernabeu, he said.
This is one of the best fixtures you could watch. I am sure the supporters will be our greatest ally. They will help us.
Pique has been an exemplary player for the Spanish national team. Whistles don t help anybody.
Deadline Day 2005: sign a certain 19 year old set for greatness at the Santiago Bernabeu !
— LaLiga (@LaLigaEN)
Spain will be without Diego Costa, however, as the striker has not played this season for Chelsea due to a stand-off with the Premier League champions over his desire to return to former club Atletico Madrid.
I could say a thousand things on Diego Costa, Ramos added. Every player plans his holidays and his life as he sees fit. I don t know about the matter [with Chelsea] so I can t say anything about that.
I hope that if right now he has more time to rest then he can come back with the same attitude as ever.